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Case Reports
. 2017 Apr 13;32(4):358-360.
doi: 10.5606/ArchRheumatol.2017.6321. eCollection 2017 Dec.

Breast Involvement in Anti-Neutrophil Cytoplasmic Antibodies Positive Granulomatosis With Polyangiitis in a 64-Year-Old Female Patient

Monika Ryba  1 , Andrzej Konieczny  1 , Zbigniew Hruby  1
Affiliations
Case Reports

Breast Involvement in Anti-Neutrophil Cytoplasmic Antibodies Positive Granulomatosis With Polyangiitis in a 64-Year-Old Female Patient

Monika Ryba et al. Arch Rheumatol. .

Abstract

In this article, we present a case of a female patient suffering from granulomatosis and polyangiitis with active glomerular disease, who developed exacerbation of pulmonary vasculitis and palpable tumors of right breast. A possibility of neoplastic disease was excluded by histopathological examination of percutaneous biopsy specimen, revealing granulomatous inflammatory infiltrate, without any features of neoplasia. Moreover, both pulmonary and breast lesions subsided following intensification of immunosuppressive/antiinflammatory treatment.

Keywords: Anti-neutrophil cytoplasmic antibodies; breast; glomerulonephritis; granulomatosis with polyangiitis.

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Conflict of interest statement

Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Figure 1
Figure 1. Chest X-ray demonstrating infiltrate in upper left lateral field of left lung.
Figure 2
Figure 2. Breast biopsy. Mixed inflammatory infiltrate of lymphocytes and neutrophils involving mainly small vessels (H-E¥400).
See this image and copyright information in PMC

References

    1. Lie JT. Wegener's granulomatosis: histological documentation of common and uncommon manifestations in 216 patients. Vasa. 1997;26:261–270. - PubMed
    1. Barczynska T, Dankiewicz-Fares I, Bilinska- Reszkowska H, Zalewska J, Jeka S. Atypical location of Wegener’s granulomatosis with breast involvement: case report. Ann Acad Med Stetin. 2011;57:70–76. - PubMed
    1. Neralic-Meniga I, Ivanovi-Herceg Z, Mazuranic I, Puljic I, Zekan M, Gorecan M, et al. Wegener's granulomatosis of the breast. Wien Klin Wochenschr. 2006;118:120–123. - PubMed
    1. Allende DS, Booth CN. Wegener’s granulomatosis of the breast: a rare entity with daily clinical relevance. Ann Diagn Pathol. 2009;13:351–357. - PubMed
    1. Naz SM, Fairburn K. Pseudotumor of the breast: an unusual presentation of Wegener’s granulomatosis. Breast J. 2005;11:295–296. - PubMed

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