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Review
. 2018 Jun;97(24):e11113.
doi: 10.1097/MD.0000000000011113.

Primary small cell carcinoma of the ureter: Case report and review of the literature

Fabiola Farci  1 , Francesca Manassero, Ramona Baldesi, Annamaria Bartolucci, Laura Boldrini, Cesare Selli, Pinuccia Faviana
Affiliations
Review

Primary small cell carcinoma of the ureter: Case report and review of the literature

Fabiola Farci et al. Medicine (Baltimore). 2018 Jun.

Abstract

Rationale: Primitive small cell carcinoma of the ureter is extremely rare, in this case report is meticulously described its aggressive clinical course and the pathological clues that help with the diagnosis. Also, a detailed table with the clinico-pathological features of analogous case reports in literature is provided.

Patient concerns: A 79-year-old female presented with gross hematuria and flank pain.

Diagnoses: Small cell carcinoma of the ureter. The surgical specimen showed a mixed histology of small cell carcinoma and transitional cell carcinoma; the common neuroendocrine markers (chromogranin A, synaptophysin, CD56) were positive, and vimentin and thyroid transcription factor 1 were negative. The patient had an advanced stage at presentation with regional nodes involvement (pT3N1).

Interventions: Segmental ureterectomy was performed but it was only possible to administer 1 cycle of platinum-based adjuvant chemotherapy due to the rapid decline of her clinical parameters.

Outcomes: The disease rapidly spread locally and metastasized.

Lesson: The clinicians must be aware of this aggressive tumor with silent clinical course and advanced stages at presentation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
(A) Panoramic view of the ureteral tumor, hematoxylin–eosin stain (H&E). (B) The transitional cell carcinoma (red triangle) infiltrates the ureteral wall together with the small cell carcinoma (SCC) component with a clear lymphovascular invasion (black triangle) (H&E 10x). (C) The transitional cell carcinoma is intermixed with the SCC (H&E 20x). (D–F) The neuroendocrine markers are all positive in the SCC component (D: CD56, 10x; E: synaptophysin, 10x; F: chromogranin-A, 2x). (G) Ki-67 is remarkably high, especially in the SCC component of the tumor (2x). (H) TTF-1 immunohistochemistry is completely negative (2x). (I) The transitional cell carcinoma is CK7 positive (2x).
See this image and copyright information in PMC

References

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