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Review
. 2018 Jun;97(24):e11115.
doi: 10.1097/MD.0000000000011115.

High-dose fulvestrant as third-line endocrine therapy for breast cancer metastasis to the left kidney: A case report and literature review

Dandan Xia  1 , Huiyu Wang, Runjie Wang, Chaoying Liu, Junying Xu
Affiliations
Review

High-dose fulvestrant as third-line endocrine therapy for breast cancer metastasis to the left kidney: A case report and literature review

Dandan Xia et al. Medicine (Baltimore). 2018 Jun.

Abstract

Rationale: Endocrine therapy plays an important role in the treatment of patients with hormone receptor-positive breast cancer. Renal metastasis of breast cancer is rare in clinical practice.

Patient concerns: We present here a 54-year-old woman with breast cancer after first line chemotherapy and second line endocrinotherapy (i.e., toremifene & exemestane) failure.

Diagnoses: The patient was rarely diagnosed breast cancer metastasis to the kidney and a positive hormone status (ER and PR) but was negative for human epidermal factor receptor 2 (HER2).

Interventions: The patient was treated with a high dose of fulvestrant (SERD; 500 mg) by intramuscular injection once per month.

Outcomes: The patient's condition significantly improved as measured by a decrease in the renal and pulmonary masses; symptoms including dry cough and blood phlegm also improved.

Lessons: Endocrinotherapy with high-dose fulvestrant may provide benefits for patients with HR+/HER2- advanced breast cancer with renal metastasis after SERMs failure.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Lung metastases before and following chemotherapy (red arrow)/fulvestrant (azure arrow).
Figure 2
Figure 2
Renal metastasis before and following chemotherapy (red arrow)/fulvestrant (azure arrow).
See this image and copyright information in PMC

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