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Comment
. 2018 Jun 13;23(6):691-692.
doi: 10.1016/j.chom.2018.05.020.

A Microbial Drugstore for Motility

John F Cryan  1 , Gerard Clarke  2 , Timothy G Dinan  2 , Harriet Schellekens  3
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A Microbial Drugstore for Motility

John F Cryan et al. Cell Host Microbe. .
Free article

Abstract

While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.

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