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Comment
. 2018 Jun 13;23(6):697-699.
doi: 10.1016/j.chom.2018.05.019.

Cell Entry of Influenza A Viruses: Sweet Talk between HA and CaV1.2

Markus Hoffmann  1 , Stefan Pöhlmann  2
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Cell Entry of Influenza A Viruses: Sweet Talk between HA and CaV1.2

Markus Hoffmann et al. Cell Host Microbe. .
Free article

Abstract

Influenza A viruses attach to sialic acids on host cells. In this issue of Cell Host & Microbe, Fujioka et al. (2018) show that binding to a specific sialylated cellular protein facilitates infection: engagement of sialic acids linked to the Ca2+ channel CaV1.2 induces Ca2+ oscillations, which promote infectious entry.

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