Penicisteroid C: New polyoxygenated steroid produced by co-culturing of Streptomyces piomogenus with Aspergillus niger

Ahmed S Abdel-Razek¹, Abdelaaty Hamed², Marcel Frese³, Norbert Sewald³, Mohamed Shaaban⁴

Affiliations

¹ Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Microbial Chemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, El-Buhouth St. 33, Dokki, Cairo 12622, Egypt.
² Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.
³ Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany.
⁴ Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, El-Buhouth St. 33, Dokki, Cairo 12622, Egypt. Electronic address: mshaaba@gmail.com.

PMID: 29902496
DOI: 10.1016/j.steroids.2018.06.005

Penicisteroid C: New polyoxygenated steroid produced by co-culturing of Streptomyces piomogenus with Aspergillus niger

Ahmed S Abdel-Razek et al. Steroids. 2018 Oct.

. 2018 Oct:138:21-25.

doi: 10.1016/j.steroids.2018.06.005. Epub 2018 Jun 15.

Authors

Ahmed S Abdel-Razek¹, Abdelaaty Hamed², Marcel Frese³, Norbert Sewald³, Mohamed Shaaban⁴

Affiliations

¹ Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Microbial Chemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, El-Buhouth St. 33, Dokki, Cairo 12622, Egypt.
² Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.
³ Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany.
⁴ Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, El-Buhouth St. 33, Dokki, Cairo 12622, Egypt. Electronic address: mshaaba@gmail.com.

PMID: 29902496
DOI: 10.1016/j.steroids.2018.06.005

Abstract

Penicisteroid C, a new polyoxygenated steroid was isolated from co-cultivation of Streptomyces piomogenus AS63D and Aspergillus niger using solid-state fermentation on rice medium. Additional diverse eleven known metabolites were identified: Fumigaclavine C, fumiquinazoline C, physcion, methylsulochrin, methyllinoleate, glycerol linoleate, cerebroside A, thymine, adenine, thymidine and adenosine. The structure of penicisteroid C was determined by HRESIMS, 1D and 2D NMR data. The antimicrobial and in vitro cytotoxic activities of the microbial extract and penicisteroid C were reported as well.

Keywords: Antimicrobial activity; Aspergillus niger; Co-cultivation; Cytotoxicity; Penicisteroid C; Sterol; Streptomyces piomogenus.

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Penicisteroid C: New polyoxygenated steroid produced by co-culturing of Streptomyces piomogenus with Aspergillus niger

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Penicisteroid C: New polyoxygenated steroid produced by co-culturing of Streptomyces piomogenus with Aspergillus niger

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