[A case-control study on the relationship between food preference and lung cancer and mesothelioma in a rural area with naturally occurring asbestos]

Abstract

Objective: To understand the relationship between food preference and lung cancer or malignant pleural mesothelioma and the interactive effect between food preference and asbestos exposure in a rural area with naturally occurring asbestos.

Methods: At the basis of the cohort of Dayao in Yunnan, we performed a 1 ∶ 2 casecontrol study including 53 cases( 23 cases for lung cancer and 26 cases for mesothelioma)and 106 age-and sex-matched normal healthy controls. In order to study the protective effect of food preference and the interactive effect between food preference and asbestos exposure, conditional logistic regression was used to estimate adjusted odds ratios( OR)and their 95% confidence intervals( CI) in both unvaried and multivariate analyses.

Results: Both green tea and wild mushroom were inversely associated with lung cancer ormalignant pleural mesothelioma, and the adjusted ORs were: 0. 88( 95% CI 0. 66-0. 87) for green tea, 0. 85( 95% CI 0. 23- 0. 95) for wild mushroom intake. Food preference to wild mushroom modified the associations of Crocidolite ' s contacting, Respectively, relative excess risk due to interaction( RERI), attributable proportion due to interaction( API), synergy index( S) were 0. 86, 0. 26 and 0. 61.

Conclusion: Both green tea and wild mushroom might serve as protective factors on lung cancer or malignant pleural mesothelioma.

Keywords: case-control study; crocidolite; food preference; lung cancer; malignant pleural mesothelioma.