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. 1985 May;27(5):876-8.
doi: 10.1128/AAC.27.5.876.

In vitro efficacy of sulbactam combined with ampicillin against anaerobic bacteria

H M Wexler, B Harris, W T Carter, S M Finegold

In vitro efficacy of sulbactam combined with ampicillin against anaerobic bacteria

H M Wexler et al. Antimicrob Agents Chemother. 1985 May.

Abstract

An ampicillin-sulbactam combination was compared with ampicillin alone, chloramphenicol, clindamycin, and metronidazole against 272 strains of anaerobic bacteria. Chloramphenicol and ampicillin-sulbactam were the most effective, inhibiting 98 to 99% of strains tested at breakpoint (16 micrograms/ml). The combination of sulbactam and ampicillin was much more effective than ampicillin alone against Bacteroides fragilis strains but did not differ substantially from ampicillin alone against Fusobacterium spp., gram-positive rods, and gram-positive cocci.

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