[Effect of CGMCC No. 8730 Eurotium cristatum fermented dark tea extract on body weight and blood lipid in two dyslipidemia rat models]

Abstract

Objective: To investigate the effect of the CGMCC No. 8730 Eurotium cristatum fermented dark tea on body weight and blood lipid.

Methods: 1. Egg yolk emulsion rat model 40 male Sprague-Dawley( SD) rats were randomly divided into 5groups, given distilled water or the Eurotium cristatum fermented dark tea extract by intragastric administration for 11 days, then fasted and intraperitoneal injected with distilled water or egg yolk emulsion. The next day rats were taken blood and tested for blood lipid. Body weight were recorded regularly. 2. High-fat diet induced rat model 50 male SD rats were randomly divided into 5 groups fed with normal or 60 kcal% high-fat diet, given distilled water or the Eurotium cristatum fermented dark tea extract byintragastric administration for 9 weeks. Blood lipid was tested at baseline( 1st week) and endpoint( 9th week), and body fat ratio was calculated from perirenal and epididymal fat weight at endpoint. Body weight, food intake and energy intake was weekly recorded.

Results: 1. Body weight and serum triglycerides of 2500 mg / kg Eurotium cristatum fermented dark tea extract group were significantly decreased foregg yolk emulsion rat model. 2. Body weight, serum triglycerides, food intake and energy intake of 250 mg / kg and 750 mg / kg Eurotium cristatum fermented dark tea extract group were significantly decreased forhigh-fat diet induced rat model.

Conclusion: The CGMCC No. 8730 Eurotium cristatum fermented dark tea extract decreases body weight andserum triglycerides for SD rats.

Keywords: Eurotium cristatum(CGMCC No. 8730); blood lipid; body weight; dark tea.