Shear elegance: A novel screen uncovers a mechanosensitive GPCR

Ruby M Lam^{1

2}, Alexander T Chesler³

Affiliations

¹ National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD.
² Brown-National Institutes of Health Graduate Partnerships Program, Brown University, Providence, RI.
³ National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD alexander.chesler@nih.gov.

Comment

Ruby M Lam et al. J Gen Physiol. 2018.

. 2018 Jul 2;150(7):907-910.

doi: 10.1085/jgp.201812101. Epub 2018 Jun 14.

Ruby M Lam^{1

2}, Alexander T Chesler³

¹ National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD.
² Brown-National Institutes of Health Graduate Partnerships Program, Brown University, Providence, RI.
³ National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD alexander.chesler@nih.gov.

Abstract

Lam and Chesler highlight the recent discovery of a G protein–coupled receptor involved in detecting mechanical shear stress.

GPR68 Senses Flow and Is Essential for Vascular Physiology.
Xu J, Mathur J, Vessières E, Hammack S, Nonomura K, Favre J, Grimaud L, Petrus M, Francisco A, Li J, Lee V, Xiang FL, Mainquist JK, Cahalan SM, Orth AP, Walker JR, Ma S, Lukacs V, Bordone L, Bandell M, Laffitte B, Xu Y, Chien S, Henrion D, Patapoutian A. Xu J, et al. Cell. 2018 Apr 19;173(3):762-775.e16. doi: 10.1016/j.cell.2018.03.076. Cell. 2018. PMID: 29677517 Free PMC article.

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