The Microbiome - The Unscheduled Parameter for Future Therapies

Abstract

The microbiome is defined as the total of cellular microorganisms of baczerial, viral or e. g., parasite origin living on the surface of a body. Within the anatomical areas of otorhinolaryngology, a significant divergence and variance can be demonstrated. For ear, nose, throat, larynx and cutis different interactions of microbiome and common factors like age, diet and live style factors (e. g., smoking) have been detected in recent years. Besides, new insights hint at a passible pathognomic role of the microbiome towards diseases in the ENT area. This review article resumes the present findings of this rapidly devloping scientific area.

Fig. 1

Number of publications listed in pubmed with the key words of “microbiome“ (total) or (microbiome AND (Rhinology or otology or otitis or nose or sinus or (head and neck) or laryngology); classified here as “ENT” (last retrieved on October 1, 2017).

Fig. 2

Open questions on the significance of the microbiome.

Fig. 3

Taxonomic classification in the international use.

Fig. 4

Procedure of a microbiome study with possible influencing factors (modified according to 7 ).

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Anzahl der von Pubmed aufgeführten Publikationen nach den Suchbegriffen „microbiome“ (Total) bzw. (microbiome AND (rhinology or Otology or otitis or nose or sinus or (Head and Neck) or laryngology), hier als „HNO“ aufgeführt (Stichtag: 01.10.2017).

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Offene Frage zur Bedeutung des Mikrobiomes.

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Taxonomische Rangstufen im internationalen Sprachgebrauch.

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Ablaufschritte einer Mikrobiom-Studie mit möglichen Einflussfaktoren (modifiziert nach 7 ).