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Comment
. 2018 Jun 15:7:e38297.
doi: 10.7554/eLife.38297.

Rethinking the tools of the RNA world

Antony Crisp  1 , Thomas Carell  1
Affiliations
Comment

Rethinking the tools of the RNA world

Antony Crisp et al. Elife. .

Abstract

An artificially evolved ribozyme can catalyse the synthesis of RNA by using trinucleotide triphosphates as building blocks.

Keywords: RNA; biochemistry; chemical biology; molecular evolution; none; origins of life; ribosome; ribozyme; triplets.

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Conflict of interest statement

AC, TC No competing interests declared

Figures

Figure 1.
Figure 1.. Comparing monomer and triplet polymerisation in RNA-templated primer extension.
(A) An RNA polymerase ribozyme (RPR; black circle) adds a mononucleotide triphosphate (PPPN) building block to the primer (brown line) in a primer/template duplex (left). This process can be repeated (right). (B) The triplet polymerase ribozyme developed by Attwater et al. (blue circle) adds trinucleotide triphosphate (PPPNNN) building blocks and has several advantages: for example, it does not always require a primer and can copy RNA sequences in both directions. (C) The chemical structure of a trinucleotide triphosphates building block, showing the three nucleotide bases.
See this image and copyright information in PMC

Comment on

References

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