Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Nov;37(9):602-608.
doi: 10.1016/j.eimc.2018.05.008. Epub 2018 Jun 12.

Use of ribavirin in viruses other than hepatitis C. A review of the evidence

[Article in English, Spanish]
German Ramírez-Olivencia  1 , Miriam Estébanez  2 , Francisco Javier Membrillo  2 , Maria Del Carmen Ybarra  2
Affiliations
Review

Use of ribavirin in viruses other than hepatitis C. A review of the evidence

[Article in English, Spanish]
German Ramírez-Olivencia et al. Enferm Infecc Microbiol Clin (Engl Ed). 2019 Nov.

Abstract
in English, Spanish

Ribavirin is a molecule with antiviral activity against different viruses. In clinical practice, it has made its niche almost exclusively for the treatment of the hepatitisC virus. However, there are other diseases in which it could be of benefit and it has the advantage of being suitable for oral, intravenous and inhaled administration. We conducted a review of the indications of the main drug agencies (Spanish, European and American) and other possible indications, mainly haemorrhagic fevers and coronavirus.

La ribavirina es una molécula con actividad antiviral sobre diferentes virus. Ha encontrado su hueco en la práctica clínica de forma casi exclusiva para el tratamiento del virus de la hepatitis C, pero existen otras enfermedades que podrían beneficiarse de su empleo. Su disponibilidad para administración por vía oral, por vía intravenosa e inhalada es una característica beneficiosa. En este trabajo se realiza una revisión de las indicaciones en las principales agencias del medicamento (española, europea y americana), así como de otras posibles indicaciones, principalmente sobre fiebres hemorrágicas y coronavirus.

Keywords: 1-f8-D-Ribofuranosil-1,2,4-triazol-3-carboxamida; 1-f8-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide; Ribavirin; Ribavirina; Virazole.

PubMed Disclaimer

References

    1. Sidwell R.W., Huffman J.H., Khare G.P., Allen L.B., Witkowski J.T., Robins R.K. Broad-spectrum antiviral activity of Virazole: 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science. 1972;177:705–706. - PubMed
    1. Graci J.D., Cameron C.E. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol. 2006;16:37–48. - PMC - PubMed
    1. Agencia Española de Medicamentos y Productos Sanitarios, AEMPS. Available from: https://www.aemps.gob.es/ [accessed 26.11.17].
    1. European Medicines Agency. Available from: http://www.ema.europa.eu/ema/ [accessed 26.11.17].
    1. U S Food and Drug Administration Home Page. Available from: https://www.fda.gov/ [accessed 26.11.17].

MeSH terms