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Comment
. 2018 Aug;8(8):905-906.
doi: 10.1158/2159-8290.CD-NB2018-078. Epub 2018 Jun 15.

Antibiotics Protect against Liver Tumors in Mice

No authors listed
Comment

Antibiotics Protect against Liver Tumors in Mice

No authors listed. Cancer Discov. 2018 Aug.

Abstract

Researchers have discovered how the gut microbiome affects tumor development in the mouse liver. By treating mice with antibiotics, they showed that depleting gut commensal bacteria enhances certain primary bile acids in the liver. This causes natural killer T cells to accumulate there, where they protect against tumors. A trial to determine whether this mechanism also operates in humans is being planned.

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  • Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells.
    Ma C, Han M, Heinrich B, Fu Q, Zhang Q, Sandhu M, Agdashian D, Terabe M, Berzofsky JA, Fako V, Ritz T, Longerich T, Theriot CM, McCulloch JA, Roy S, Yuan W, Thovarai V, Sen SK, Ruchirawat M, Korangy F, Wang XW, Trinchieri G, Greten TF. Ma C, et al. Science. 2018 May 25;360(6391):eaan5931. doi: 10.1126/science.aan5931. Science. 2018. PMID: 29798856 Free PMC article.

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