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Comment
. 2018 Nov 1;24(21):5193-5194.
doi: 10.1158/1078-0432.CCR-18-1475. Epub 2018 Jun 15.

Unexpected Benefits of Aging for Favorable Responses to PD-1 Blockade in Melanoma?

Graham Pawelec  1   2
Affiliations
Comment

Unexpected Benefits of Aging for Favorable Responses to PD-1 Blockade in Melanoma?

Graham Pawelec. Clin Cancer Res. .

Abstract

Immunosenescence might be expected to reduce the efficacy of checkpoint blockade, which depends on a functionally intact immune system. However, it seems that older patients with melanoma may respond better to anti-PD-1 treatment than younger patients, possibly due to their having fewer regulatory T cells relative to CD8+ T cells within tumor deposits. Clin Cancer Res; 24(21); 5193-4. ©2018 AACR See related article by Kugel et al., p. 5347.

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  • Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations.
    Kugel CH 3rd, Douglass SM, Webster MR, Kaur A, Liu Q, Yin X, Weiss SA, Darvishian F, Al-Rohil RN, Ndoye A, Behera R, Alicea GM, Ecker BL, Fane M, Allegrezza MJ, Svoronos N, Kumar V, Wang DY, Somasundaram R, Hu-Lieskovan S, Ozgun A, Herlyn M, Conejo-Garcia JR, Gabrilovich D, Stone EL, Nowicki TS, Sosman J, Rai R, Carlino MS, Long GV, Marais R, Ribas A, Eroglu Z, Davies MA, Schilling B, Schadendorf D, Xu W, Amaravadi RK, Menzies AM, McQuade JL, Johnson DB, Osman I, Weeraratna AT. Kugel CH 3rd, et al. Clin Cancer Res. 2018 Nov 1;24(21):5347-5356. doi: 10.1158/1078-0432.CCR-18-1116. Epub 2018 Jun 13. Clin Cancer Res. 2018. PMID: 29898988 Free PMC article.

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