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Comment
. 2018 Jun 15;3(24):eaat9779.
doi: 10.1126/sciimmunol.aat9779.

Who regulates whom: ZNF341 is an additional player in the STAT3/TH17 song

Avery August  1
Affiliations
Comment

Who regulates whom: ZNF341 is an additional player in the STAT3/TH17 song

Avery August. Sci Immunol. .

Abstract

Deficiency of ZNF341, a transcription factor featuring 12 Cys2His2 zinc fingers that regulates the expression and autoinduction of STAT3 (signal transducer and activator of transcription 3), results in hyper-immunoglobulin E syndrome and defective T helper 17 cell differentiation in humans.

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Conflict of interest statement

Conflict of Interest Disclosure

The author declares no competing financial interests.

Figures

Figure 1.
Figure 1.. ZNF341, STAT3 and Th17 differentiation, a more complex song.
A) Th17 differentiation requires TCR signals (not shown) along with cytokines IL-6, TGF-β, and/or IL-1β. Signaling through the IL-6 receptor triggers activation of JAK2, which phosphorylates STAT3, driving its dimerization and nuclear localization. STAT3 cooperates with other transcription factors such as SMADs to drive expression of critical genes required for Th17 differentiation. ZNF341 regulates STAT3 expression and its autoinduction during Th17 differentiation. (B) Key structural motifs within ZNF341 and the location of mutations in HIES patients identified by Beziat et al and Frey-Jacobs et al,.
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Comment on

  • A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity.
    Béziat V, Li J, Lin JX, Ma CS, Li P, Bousfiha A, Pellier I, Zoghi S, Baris S, Keles S, Gray P, Du N, Wang Y, Zerbib Y, Lévy R, Leclercq T, About F, Lim AI, Rao G, Payne K, Pelham SJ, Avery DT, Deenick EK, Pillay B, Chou J, Guery R, Belkadi A, Guérin A, Migaud M, Rattina V, Ailal F, Benhsaien I, Bouaziz M, Habib T, Chaussabel D, Marr N, El-Benna J, Grimbacher B, Wargon O, Bustamante J, Boisson B, Müller-Fleckenstein I, Fleckenstein B, Chandesris MO, Titeux M, Fraitag S, Alyanakian MA, Leruez-Ville M, Picard C, Meyts I, Di Santo JP, Hovnanian A, Somer A, Ozen A, Rezaei N, Chatila TA, Abel L, Leonard WJ, Tangye SG, Puel A, Casanova JL. Béziat V, et al. Sci Immunol. 2018 Jun 15;3(24):eaat4956. doi: 10.1126/sciimmunol.aat4956. Sci Immunol. 2018. PMID: 29907691 Free PMC article.

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References

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