Review
[Recent advances in study of long β(2)-adrenoceptor agonist]
[Article in
Chinese]
- PMID: 29908535
Item in Clipboard
Review
[Recent advances in study of long β(2)-adrenoceptor agonist]
[Article in
Chinese]
Yao Xue Xue Bao.
2016 Dec.
Abstract
β2-Adrenoceptor agonists are highly effective bronchodilators and are widely used in the treatment of both chronic obstructive pulmonary disease (COPD) and asthma. In the last 15 years, there has been great interest within the pharmaceutical industry in the discovery of a long β2-adrenoceptor agonist for a mono-therapy or combination therapy. The search for new long-acting β2-adrenoreceptor agonists (LABA’s), for the treatment of asthma and COPD, has become a very active area of drug discovery. This article reviews the mechanisms, potential candidates and research advances of long β2-adrenoceptor agonists.
Similar articles
-
Corticosteroids and adrenoceptor agonists: the compliments for combination therapy in chronic airways diseases.Eur J Pharmacol. 2006 Mar 8;533(1-3):28-35. doi: 10.1016/j.ejphar.2005.12.049. Epub 2006 Feb 7. Eur J Pharmacol. 2006. PMID: 16457807 Review.
-
Beta-adrenoceptor responses of the airways: for better or worse?Eur J Pharmacol. 2006 Mar 8;533(1-3):15-27. doi: 10.1016/j.ejphar.2005.12.060. Epub 2006 Feb 15. Eur J Pharmacol. 2006. PMID: 16469310 Review.
-
β2-agonist therapy in lung disease.Am J Respir Crit Care Med. 2013 Apr 1;187(7):690-6. doi: 10.1164/rccm.201209-1739PP. Am J Respir Crit Care Med. 2013. PMID: 23348973 Review.
-
Characteristics of AZD9708, a novel, selective β2-adrenoceptor agonist with rapid onset and long duration of action.Pulm Pharmacol Ther. 2012 Aug;25(4):293-302. doi: 10.1016/j.pupt.2012.05.008. Epub 2012 May 29. Pulm Pharmacol Ther. 2012. PMID: 22659538
-
β2 Agonists.Handb Exp Pharmacol. 2017;237:23-40. doi: 10.1007/164_2016_64. Handb Exp Pharmacol. 2017. PMID: 27878470 Free PMC article. Review.