Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018;64(5):446-456.
doi: 10.1159/000489172. Epub 2018 Jun 15.

HIV and Aging - Perhaps Not as Dramatic as We Feared?

Tanja Engel  1 , Marieke Raffenberg  1 , Catia Marzolini  2 , Matthias Cavassini  3 , Helen Kovari  4 , Barbara Hasse  4 , Philip E Tarr  1
Affiliations
Free article
Review

HIV and Aging - Perhaps Not as Dramatic as We Feared?

Tanja Engel et al. Gerontology. 2018.
Free article

Abstract

Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to "metabolic" complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. The aims of this viewpoint paper are to summarize recent data and to examine the possibility that the problem of aging-related morbidity in HIV might not be as dramatic as previously believed.

Keywords: Aging; Comedications; Comorbidities; Drug interactions; Frailty; HIV; Polypharmacy.

PubMed Disclaimer

Publication types

MeSH terms