doi: 10.1016/0014-2999(85)90755-1.
Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids
- PMID: 2990951
- DOI: 10.1016/0014-2999(85)90755-1
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Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids
Eur J Pharmacol.
.
Abstract
The effects of the stereoisomers dextrorphan and levorphanol on the excitation of spinal neurons by electrophoretically administered excitatory amino acids were studied in pentobarbitone-anaesthetised rats. Both isomers reduced responses to N-methyl-DL-aspartate (NMA), dextrorphan being both more selective and more potent than levorphanol in this respect. This observation supports the proposal that the NMA-blocking activity of a variety of drugs with psychotomimetic properties is subserved by actions at phencyclidine (PCP)/sigma opiate receptors.
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