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. 1985 May 8;111(2):185-90.
doi: 10.1016/0014-2999(85)90755-1.

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids

J Church, D Lodge, S C Berry

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids

J Church et al. Eur J Pharmacol. .

Abstract

The effects of the stereoisomers dextrorphan and levorphanol on the excitation of spinal neurons by electrophoretically administered excitatory amino acids were studied in pentobarbitone-anaesthetised rats. Both isomers reduced responses to N-methyl-DL-aspartate (NMA), dextrorphan being both more selective and more potent than levorphanol in this respect. This observation supports the proposal that the NMA-blocking activity of a variety of drugs with psychotomimetic properties is subserved by actions at phencyclidine (PCP)/sigma opiate receptors.

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