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Review
. 2018 Jun;31(2):126-134.
doi: 10.1016/j.beha.2018.01.002. Epub 2018 Feb 2.

GMP CAR-T cell production

Adrian P Gee  1
Affiliations
Review

GMP CAR-T cell production

Adrian P Gee. Best Pract Res Clin Haematol. 2018 Jun.

Abstract

The clinical success achieved using CD19-directed CAR-T cells has stimulated many academic institutions to explore the feasibility of manufacturing these, and other CAR-T cells, in-house. This article reviews the issues that must be addressed in order to achieve this goal. It includes the manufacturing infrastructure, the regulatory environment, practical aspects of production, and the costs involved.

Keywords: CAR-T cells; Good manufacturing practices; Manufacturing.

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