doi: 10.1016/0014-5793(85)81236-9.
A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle
- PMID: 2991006
- DOI: 10.1016/0014-5793(85)81236-9
Item in Clipboard
A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle
FEBS Lett.
.
Free article
Abstract
The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a beta-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production. These results suggest a role for adrenaline and calmodulin in modulating cyclic AMP levels in mammary tissue during the lactogenic cycle.
Similar articles
-
Inhibition by cyclic AMP of lactose production in lactating guinea pig mammary gland slices.Biochim Biophys Acta. 1975 May 5;392(1):20-5. doi: 10.1016/0304-4165(75)90162-2. Biochim Biophys Acta. 1975. PMID: 164955
-
Changes in the cyclic 3', 5'-adenosine monophosphate system of rat mammary gland during lactation cycle.J Dairy Sci. 1975 Jun;58(6):861-9. doi: 10.3168/jds.S0022-0302(75)84650-9. J Dairy Sci. 1975. PMID: 167062
-
Calmodulin and cyclic nucleotide-phosphodiesterase activities in rat mammary gland during the lactogenic cycle.FEBS Lett. 1981 Dec 21;136(1):127-30. doi: 10.1016/0014-5793(81)81229-x. FEBS Lett. 1981. PMID: 6274696 No abstract available.
-
Gamma-glutamyltranspeptidase activity and cyclic AMP levels in rat liver and mammary gland during the lactogenic cycle and in the oestradiol-progesterone pseudo-induced pregnancy.FEBS Lett. 1979 Mar 1;99(1):215-8. doi: 10.1016/0014-5793(79)80282-3. FEBS Lett. 1979. PMID: 35369 No abstract available.
-
Forskolin: a unique diterpene activator of cyclic AMP-generating systems.J Cyclic Nucleotide Res. 1981;7(4):201-24. J Cyclic Nucleotide Res. 1981. PMID: 6278005 Review.
Cited by
-
Effect of anticalmodulin drugs on the action of yeast alpha factor pheromone.Arch Microbiol. 1986 Jun;145(1):104-6. doi: 10.1007/BF00413035. Arch Microbiol. 1986. PMID: 3530168
-
Effect of nucleosides and nucleotides and the relationship between cellular adenosine 3':5'-cyclic monophosphate (cyclic AMP) and germ tube formation in Candida albicans.Mycopathologia. 1992 Sep;119(3):147-56. doi: 10.1007/BF00448812. Mycopathologia. 1992. PMID: 1331793
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
