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. 2018;2018(1):CD012934.
doi: 10.1002/14651858.CD012934. Epub 2018 Jan 24.

Symptom screening for active tuberculosis in pregnant women living with HIV

Sylvia M LaCourse  1 , Lisa M Cranmer  2 , Adrie Bekker  3 , Karen R Steingart  4 , Danae Black  5 , David J Horne  6 , Eyal Oren  7 , Sherri Pals  8 , Surbhi Modi  8 , Jyoti Mathad  9
Affiliations

Symptom screening for active tuberculosis in pregnant women living with HIV

Sylvia M LaCourse et al. Cochrane Database Syst Rev. 2018.

Abstract

Editorial note This protocol will not progress to review stage as it no longer meets Cochrane's methodological standards. This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting. To investigate potential sources of heterogeneity of the accuracy of the four-symptom screen between studies including: ART status, CD4 cell count, gestational age, pregnancy stage (pregnancy vs. postpartum), screening test definition of cough (any cough vs. cough greater than 2 weeks).To describe the accuracy of single symptoms included within the four-symptom screen, additioal symptoms or symptom combinations, for identifying active TB in pregnant PLHIV. For example, additional symptoms may include failure to gain weight or fatigue.

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Conflict of interest statement

DECLARATIONS OF INTEREST The review authors (EO, AB, DB, LC, DH, JM, SL, SM, KRS, SP) have no known conflicts of interest. LC, DH, SL, JM, and SM have conducted primary research regarding evaluating symptom screening for TB in pregnant PLHIV.

Figures

1
1
Algorithm for TB screening in adults and adolescents living with HIV in HIV‐prevalent and resource‐constrained settings. Reprinted from: Guidelines for intensified tuberculosis case‐finding and isoniazid preventive therapy for people living with HIV in resource‐constrained settings. Copyright: WHO 2011a.
See this image and copyright information in PMC

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