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. 1985 Aug 25;260(18):10236-41.

The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line

E Sausville, D Carney, J Battey
  • PMID: 2991279
Free article

The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line

E Sausville et al. J Biol Chem. .
Free article

Abstract

The human genes for prepro-arginine-vasopressin-neurophysin II (prepro-AVP-NPII) and prepro-oxytocin-neurophysin I (prepro-OT-NPI) were cloned from a human genomic library and the nucleotide sequence of both genes was determined. The two genes are similar in their intron-exon structure, linked together with 12 kilobases intervening, and transcribed from opposite DNA strands. A human small cell lung cancer cell line, H378, produces significant quantities of pre-pro-AVP-NPII mRNA using a transcription unit predicted from the genomic DNA sequence. Despite the proximity of the actively transcribed prepro-AVP-NPII gene, transcription of prepro-OT-NPI is not detected in this cell line.

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