Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Jun 19;168(12):JC68.
doi: 10.7326/ACPJC-2018-168-12-068.

Hydrocortisone plus fludrocortisone reduced mortality at 90 days in patients with septic shock

Comment

Hydrocortisone plus fludrocortisone reduced mortality at 90 days in patients with septic shock

Brent A Duran et al. Ann Intern Med. .
No abstract available

PubMed Disclaimer

Comment on

  • Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.
    Annane D, Renault A, Brun-Buisson C, Megarbane B, Quenot JP, Siami S, Cariou A, Forceville X, Schwebel C, Martin C, Timsit JF, Misset B, Ali Benali M, Colin G, Souweine B, Asehnoune K, Mercier E, Chimot L, Charpentier C, François B, Boulain T, Petitpas F, Constantin JM, Dhonneur G, Baudin F, Combes A, Bohé J, Loriferne JF, Amathieu R, Cook F, Slama M, Leroy O, Capellier G, Dargent A, Hissem T, Maxime V, Bellissant E; CRICS-TRIGGERSEP Network. Annane D, et al. N Engl J Med. 2018 Mar 1;378(9):809-818. doi: 10.1056/NEJMoa1705716. N Engl J Med. 2018. PMID: 29490185 Clinical Trial.

Similar articles

  • Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.
    Annane D, Renault A, Brun-Buisson C, Megarbane B, Quenot JP, Siami S, Cariou A, Forceville X, Schwebel C, Martin C, Timsit JF, Misset B, Ali Benali M, Colin G, Souweine B, Asehnoune K, Mercier E, Chimot L, Charpentier C, François B, Boulain T, Petitpas F, Constantin JM, Dhonneur G, Baudin F, Combes A, Bohé J, Loriferne JF, Amathieu R, Cook F, Slama M, Leroy O, Capellier G, Dargent A, Hissem T, Maxime V, Bellissant E; CRICS-TRIGGERSEP Network. Annane D, et al. N Engl J Med. 2018 Mar 1;378(9):809-818. doi: 10.1056/NEJMoa1705716. N Engl J Med. 2018. PMID: 29490185 Clinical Trial.
  • Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial.
    COIITSS Study Investigators; Annane D, Cariou A, Maxime V, Azoulay E, D'honneur G, Timsit JF, Cohen Y, Wolf M, Fartoukh M, Adrie C, Santré C, Bollaert PE, Mathonet A, Amathieu R, Tabah A, Clec'h C, Mayaux J, Lejeune J, Chevret S. COIITSS Study Investigators, et al. JAMA. 2010 Jan 27;303(4):341-8. doi: 10.1001/jama.2010.2. JAMA. 2010. PMID: 20103758 Clinical Trial.
  • Effect of hydrocortisone-fludrocortisone combination on mortality in septic shock: a systematic review and meta-analysis.
    Wu JY, Liu MY, Liu TH, Huang PY, Restinia M, Hsu WH, Tsai YW, Chuang MH, Hung KC, Lai CC. Wu JY, et al. Infection. 2025 Apr;53(2):553-560. doi: 10.1007/s15010-024-02381-z. Epub 2024 Aug 27. Infection. 2025. PMID: 39192056
  • Fludrocortisone dose-response relationship in septic shock: a randomised phase II trial.
    Walsham J, Hammond N, Blumenthal A, Cohen J, Myburgh J, Finfer S, Evans D, Peake S, Kruger P, McCullough J, Johnk L, Ghelani D, Billot L, Shan S, Meyer J, Rajbhandari D, Koch C, Bellomo R, Burrell LM, Young M, Roberts M, Mackenzie L, Medley G, Dalton J, Venkatesh B. Walsham J, et al. Intensive Care Med. 2024 Dec;50(12):2050-2060. doi: 10.1007/s00134-024-07616-z. Epub 2024 Sep 5. Intensive Care Med. 2024. PMID: 39235623 Free PMC article. Clinical Trial.
  • Hydrocortisone in Vasodilatory Shock.
    Venkatesh B, Cohen J. Venkatesh B, et al. Crit Care Clin. 2019 Apr;35(2):263-275. doi: 10.1016/j.ccc.2018.11.005. Epub 2019 Jan 28. Crit Care Clin. 2019. PMID: 30784608 Review.

LinkOut - more resources