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. 2018 Jul 1;19(11):913-925.
doi: 10.2217/pgs-2017-0173. Epub 2018 Jun 19.

Pharmacogenetic of voriconazole antifungal agent in pediatric patients

Sarah Allegra  1 , Giovanna Fatiguso  1 , Silvia De Francia  2 , Elisa Pirro  2 , Chiara Carcieri  1 , Jessica Cusato  1 , Amedeo De Nicolò  1 , Valeria Avataneo  1 , Giovanni Di Perri  1 , Antonio D'Avolio  1
Affiliations

Pharmacogenetic of voriconazole antifungal agent in pediatric patients

Sarah Allegra et al. Pharmacogenomics. .

Abstract

Aim: We explored the role of SNPs within the SLCO1B3, SLCO1B1, SLC22A6, ABCB1, ABCG2, SLCO3A1, CYP2C19, ABCC2, SLC22A1, ABCB11 and NR1I2 genes on voriconazole pharmacokinetics.

Patients & methods: 233 pediatric patients were enrolled. Drug plasma Ctrough was measured by a HPLC-MS method. Allelic discrimination was performed by qualitative real-time PCR.

Results: SLCO1B3 rs4149117 c.334 GT/TT (p = 0.046), ABCG2 rs13120400 c.1194 + 928 CC (p = 0.029) and ABCC2 rs717620 c.-24 GA/AA (p = 0.025) genotype groups significantly influenced Ctrough. ethnicity (p = 0.042), sex (p = 0.033), SLCO1B3 rs4149117 c.334 GT/TT (p = 0.041) and ABCB1 rs1045642 c.3435 TT (p = 0.016) have been retained in linear regression model as voriconazole predictor factors.

Conclusion: Understanding how some gene polymorphisms affect the voriconazole pharmacokinetic is essential to optimally dose this agent.

Keywords: ABCB1; ABCC2; ABCG2; SLCO1B3; therapeutic drug monitoring; triazoles.

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