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. 1985 Jul:66 ( Pt 7):1589-93.
doi: 10.1099/0022-1317-66-7-1589.

A herpes simplex virus type 1 mutant with a deletion in the polypeptide-coding sequences of the ICP4 gene

C H Schröder, J DeZazzo, K W Knopf, H C Kaerner, M Levine, J Glorioso

A herpes simplex virus type 1 mutant with a deletion in the polypeptide-coding sequences of the ICP4 gene

C H Schröder et al. J Gen Virol. 1985 Jul.

Abstract

A deletion mutant derived from herpes simplex virus type 1 (HSV-1) strain ANG was analysed. The deletion mapped within the polypeptide-coding region of the immediate-early ICP4 gene. Based on DNA sequence data the deletion was shown to comprise 84 base pairs. In the wild-type genome of strain ANG these sequences were almost completely homologous to the known sequences of HSV-1 strain 17. The ICP4 polypeptide induced by the mutant was similar in size to the wild-type ICP4 protein and was recognized by a monoclonal antibody against ICP4. The data presented suggest that the deletion corresponds to a region on the ICP4 polypeptide that is nonessential for the replication of the virus in vitro.

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