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. 2018 Aug 27;62(9):e00590-18.
doi: 10.1128/AAC.00590-18. Print 2018 Sep.

In Vitro Susceptibility of Burkholderia cepacia Complex Isolated from Cystic Fibrosis Patients to Ceftazidime-Avibactam and Ceftolozane-Tazobactam

A Van Dalem #  1 , M Herpol #  2 , F Echahidi  2 , C Peeters  3 , I Wybo  2 , E De Wachter  4 , P Vandamme  3 , D Piérard  2
Affiliations

In Vitro Susceptibility of Burkholderia cepacia Complex Isolated from Cystic Fibrosis Patients to Ceftazidime-Avibactam and Ceftolozane-Tazobactam

A Van Dalem et al. Antimicrob Agents Chemother. .

Abstract

We tested the in vitro susceptibility of ceftazidime-avibactam and ceftolozane-tazobactam and 13 other antibiotics against 91 Burkholderia cepacia complex (BCC) strains isolated from cystic fibrosis patients since 2012. The highest susceptibility (82%) was found for trimethoprim-sulfamethoxazole. Eighty-one and 63% of all BCC strains were susceptible to ceftazidime-avibactam and ceftolozane-tazobactam, respectively. For temocillin, ceftazidime, piperacillin-tazobactam, and meropenem, at least 50% of the strains were susceptible. B. stabilis seems to be more resistant than other BCC species.

Keywords: Burkholderia cepacia complex; ceftazidime-avibactam; ceftolozane-tazobactam; cystic fibrosis; in vitro susceptibility.

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