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Case Reports
. 2018 Jun 12;8(3):152-155.
doi: 10.1080/20009666.2018.1475188. eCollection 2018.

Daptomycin associated eosinophilic pneumonia: case report and differential diagnoses

Sijan Basnet  1 , Niranjan Tachamo  1 , Rashmi Dhital  1 , Biswaraj Tharu  2
Affiliations
Case Reports

Daptomycin associated eosinophilic pneumonia: case report and differential diagnoses

Sijan Basnet et al. J Community Hosp Intern Med Perspect. .

Abstract

Daptomycin is a bactericidal antibiotic approved for treatment of gram-positive skin and soft tissue infections. We present a case of an 89-year-old man who presented with fever, shortness of breath and nonproductive cough on week 4 of starting daptomycin for infective endocarditis. Computerized tomography scan showed bilateral interstitial infiltrates predominantly affecting the lower lobes. He also had peripheral eosinophilia of 6%. He was diagnosed with eosinophilic pneumonia secondary to daptomycin use. His symptoms improved with discontinuation of daptomycin and initiation of corticosteroids. Clinical correlation of pneumonia-like presentation with recent use of daptomycin should make physicians rule out this rare adverse effect for early institution of correct treatment.

Keywords: Daptomycin; adverse effect; eosinophilic pneumonia.

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Figures

Figure 1.
Figure 1.
CT scan of chest showing bilateral diffuse ground glass opacity of lung parenchyma on presentation.
Figure 2.
Figure 2.
CT scan of chest showing improved opacity of lung parenchyma 2 weeks after discontinuation of daptomycin.
See this image and copyright information in PMC

References

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