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. 1985 Aug;82(15):4987-91.
doi: 10.1073/pnas.82.15.4987.

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene

F Meijlink, T Curran, A D Miller, I M Verma

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene

F Meijlink et al. Proc Natl Acad Sci U S A. 1985 Aug.

Abstract

Transformation of fibroblasts by protooncogene fos (c-fos) requires the linkage of viral long terminal repeat (LTR) sequences and interruption of 3'-noncoding sequences. We have identified an A + T-rich stretch of 67 nucleotides, located 627-693 base pairs downstream from the coding domain and 123-189 base pairs upstream from the putative poly(A) addition site, removal of which confers transforming activity to the c-fos gene. A novel regulation of the expression of the c-fos gene is proposed, which may be functional in vivo to prevent the gene from becoming an oncogene.

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