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. 1985 Aug;82(15):5199-202.
doi: 10.1073/pnas.82.15.5199.

Monoclonal antibodies specific for p24, the major core protein of human T-cell leukemia virus type III

F di Marzo Veronese, M G Sarngadharan, R Rahman, P D Markham, M Popovic, A J Bodner, R C Gallo

Monoclonal antibodies specific for p24, the major core protein of human T-cell leukemia virus type III

F di Marzo Veronese et al. Proc Natl Acad Sci U S A. 1985 Aug.

Abstract

Four mouse hybridomas secreting monoclonal antibodies specific for p24, the major core antigen of the human T-cell leukemia virus type III (HTLV-III), have been developed, and their specificities have been partially characterized. These antibodies specifically recognized p24 of HTLV-III in extracts of HTLV-III and in HTLV-III-producing cells. No epitopes cross-reactive with HTLV-I and -II were detected with these antibodies. These hybridomas will be extremely valuable reagents in identifying expression of HTLV-III in infected cultures and in cells or tissues from patients with suspected immunodeficiency syndrome.

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