National Cancer Institute Biospecimen Evidence-Based Practices: Harmonizing Procedures for Nucleic Acid Extraction from Formalin-Fixed, Paraffin-Embedded Tissue

Affiliations

¹ 1 Kelly Government Solutions , Rockville, Maryland.
² 2 Preferred Solutions Group , Arlington, Virginia.
³ 3 Cytogenetics/Molecular Genetics Laboratory at Nationwide Children's Hospital , Columbus, Ohio.
⁴ 4 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Bethesda, Maryland.
⁵ 5 Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
⁶ 6 Canada's Michael Smith Genome Sciences Center , BC Cancer Agency, Vancouver, Canada .
⁷ 7 Human Genome Sequencing Center , Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

Sarah R Greytak et al. Biopreserv Biobank. 2018 Aug.

. 2018 Aug;16(4):247-250.

doi: 10.1089/bio.2018.0046. Epub 2018 Jun 19.

¹ 1 Kelly Government Solutions , Rockville, Maryland.
² 2 Preferred Solutions Group , Arlington, Virginia.
³ 3 Cytogenetics/Molecular Genetics Laboratory at Nationwide Children's Hospital , Columbus, Ohio.
⁴ 4 Biorepositories and Biospecimen Research Branch, Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Bethesda, Maryland.
⁵ 5 Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
⁶ 6 Canada's Michael Smith Genome Sciences Center , BC Cancer Agency, Vancouver, Canada .
⁷ 7 Human Genome Sequencing Center , Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

No abstract available

Conflict of interest statement

No conflicting financial interests exist.

1. Poste G. Bring on the biomarkers. Nature 2011;469:156–157 - PubMed
1. Taube SE, Clark GM, Dancey JE, et al. A perspective on challenges and issues in biomarker development and drug and biomarker codevelopment. J Natl Cancer Inst 2009;101:1453–1463 - PMC - PubMed
1. de Gramont A, Watson S, Ellis LM, et al. Pragmatic issues in biomarker evaluation for targeted therapies in cancer. Nat Rev Clin Oncol 2015;12:197–212 - PubMed
1. Engel KB, Vaught J, Moore HM. National Cancer Institute Biospecimen Evidence-Based Practices: A novel approach to pre-analytical standardization. Biopreserv Biobank 2014;12:148–150 - PMC - PubMed
1. Bass BP, Engel KB, Greytak SR, et al. A review of pre-analytical factors affecting molecular, protein, and morphological analysis of formalin-fixed, paraffin-embedded tissue. Arch Pathol Lab Med 2014;138:1520–1530 - PubMed