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Case Reports
. 2019 Jan;19(1):298-299.
doi: 10.1111/ajt.14972. Epub 2018 Jul 13.

Successful pregnancies after islet transplantation for type 1 diabetes

M R Rickels  1 , E Markmann  2 , A Naji  2
Affiliations
Case Reports

Successful pregnancies after islet transplantation for type 1 diabetes

M R Rickels et al. Am J Transplant. 2019 Jan.
No abstract available

Keywords: clinical research/practice; diabetes: type 1; endocrinology/diabetology; insulin/C-peptide; islet transplantation; islets of Langerhans; pregnancy.

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Conflict of interest statement

DISCLOSURE

The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation.

Figures

FIGURE 1
FIGURE 1
Metabolic control and posttransplant islet β-cell secretory capacity over 7 years following islet transplantation including 2 successful pregnancies. (A) Normoglycemia (glycosylated hemoglobin, HbA1c < 6.0% [42 mmol/mol]) was established after islet transplantation with withdrawal of insulin therapy except where reinstituted preemptively during pregnancy. (B) The incremental acute insulin response to arginine under hyperglycemic clamp conditions gives the β-cell secretory capacity as a measure of functional β-cell mass that was stable during 3 years of per protocol assessment at 74 ± 5 μU/mL, which is ~ 50% of the normal 143 ± 15 μU/mL. (C) One year following the second pregnancy, 7 years after islet transplantation and remaining off insulin therapy, continuous glucose monitoring demonstrated minimal glucose variability (glucose SD 12 mg/dL [0.7 mmol/L]) with 99% of time spent with on-target glycemia (70–140 mg/dL [3.9–7.8 mmol/L]) and essentially no (1%) time spent with hypoglycemia (< 70 mg/dL [3.9 mmol/l]). The inset shows the pretransplant continuous glucose monitoring assessment with markedly increased glucose variability (glucose SD 42 mg/dL [2.3 mmol/L]) and 22% of time spent with hypoglycemia when previously on sensor-augmented insulin pump therapy
See this image and copyright information in PMC

References

    1. Wahoff DC, Leone JP, Farney AC, Teuscher AU, Sutherland DE. Pregnancy after total pancreatectomy and autologous islet transplantation. Surgery. 1995;117(3):353–354. - PubMed
    1. Schive SW, Scholz H, Sahraoui A, et al. Graft function 1 year after pregnancy in an islet-transplanted patient. Transpl Int. 2015;28(10):1235–1239. - PubMed
    1. Assalino M, Podetta M, Demuylder-Mischler S, et al. Successful pregnancy and delivery after simultaneous islet-kidney transplantation. Am J Transplant. 2018. 10.1111/ajt.14884 - DOI - PubMed
    1. Rickels MR, Liu C, Shlansky-Goldberg RD, et al. Improvement in beta-cell secretory capacity after human islet transplantation according to the CIT07 protocol. Diabetes. 2013;62(8):2890–2897. - PMC - PubMed
    1. American Diabetes Association. 13. Management of diabetes in pregnancy: standards of medical care in diabetes-2018. Diabetes Care. 2018;41(suppl 1):S137–S143. - PubMed