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Review
. 2018 Dec;24(4):279-284.
doi: 10.1177/0260106018772170. Epub 2018 Jun 19.

Supplementation with polyunsaturated fatty acids (PUFAs) in the management of attention deficit hyperactivity disorder (ADHD)

Affiliations
Review

Supplementation with polyunsaturated fatty acids (PUFAs) in the management of attention deficit hyperactivity disorder (ADHD)

Tobias Banaschewski et al. Nutr Health. 2018 Dec.

Abstract

While pharmacotherapy and psychosocial interventions are recommended as the primary frontline treatment for attention deficit hyperactivity disorder (ADHD), alternative approaches to managing ADHD are becoming increasingly popular among patients and their families. Supplementation with polyunsaturated fatty acids (PUFAs) is an example of this. PUFA supplementation is not recommended by guidelines for managing ADHD; however, patients may still decide to use it. To provide direction to healthcare professionals (HCPs) managing ADHD, eight international experts in the field of adult and child ADHD came together for the Continuum Education Board: Omega Supplements in ADHD meeting. This commentary summarises the panel's consensus that current evidence suggests PUFA supplementation has a small beneficial effect on behaviour in children with ADHD, and that further high-quality research is needed to clearly evaluate and define its role in the management of ADHD of children, adolescents and adults. The panel concluded that in cases where patients use PUFA supplementation, HCPs should be comfortable explaining the potential gains that they may have and their possible side effects. The panel also concluded HCPs should not reinforce the idea that PUFA supplementation should replace treatment approaches with a more robust evidence base for managing ADHD.

Keywords: ADHD; Nutrition; PUFA; attention deficit hyperactivity disorder; health; omega; polyunsaturated fatty acids; supplements.

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Conflict of interest statement

Declaration of conflicting interests: During the preparation of this paper in 2017, the authors declared the following interests. TB has received funding for research grants from Vifor, Lilly, and Shire and has received honoraria/consultation fees from Actelion, Hexal Pharma, Lilly, Lundbeck, Medice, Novartis and Shire. He has participated in company speaker’s bureau for Lilly, Medice, Novartis and Shire. Along with this, he has also received an EU grant. Brendan Belsham has participated in the company sponsored speaker’s bureaus for Pharmaplan and Lundbeck as well as receiving conference sponsorships from Lundbeck, Janssen, Novartis, Lilly, Cipla, Adcock. MB has received grants/research support from Therapix Biosciences and Biohaven Pharmaceuticals as well as receiving honoraria/consultation fees from Tasly Pharmaceuticals. Other support has been accepted from NIMH and Patterson Foundation and his spouse has also received consultation fees from Tasly Pharmaceuticals. MF declares that there is no conflict of interest. MJ has received a speaker fee for four talks (2013–2017) from New Nordic Company along with a speaker fee for four roundtable meetings (2013–2017) from PCM Scientific. JK has worked as a speaker and consultant and received fees for this from Shire and Eli Lilly, along with owning a small number of shares in AstraZeneca, which were purchased 20 years before. SR is a medical writer employed at PCM Scientific, the medical education company acting as secretariat for the ADHD Continuum Nutrition Education Board, supported by an arm’s length educational grant from Soho Flordis UK Ltd. AZ has previously received research grants/support from Shire, Lundbeck, Roche, Jansen and Otsuka as well as receiving honoraria/consultant fees from Lundbeck and Otsuka. He has participated in a company sponsored speaker’s bureau for Otsuka.

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