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Review
. 2018 May;21(5):439-448.
doi: 10.22038/IJBMS.2018.25200.6238.

A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome

Setareh Sanati  1 , Bibi Marjan Razavi  2 , Hossein Hosseinzadeh  3   1
Affiliations
Review

A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome

Setareh Sanati et al. Iran J Basic Med Sci. 2018 May.

Abstract

Objectives: Metabolic syndrome, a coexisting of high blood glucose, obesity, dyslipidemia and hypertension, is an important risk factor for cardiovascular disease occurrence and mortality. Recently, there is a rising demand for herbal drugs which have less adverse effects and have shown more beneficial effects in comparison with synthetic options. Red pepper, with the scientific name of Capsicum annuum, belongs to the Solanaceae family. The lipid-lowering, antihypertensive, antidiabetic and anti-obesity effects of C. annuum have been demonstrated in several studies.

Materials and methods: In this review, we summarized different animal and human studies on the effect of red pepper and capsaicin on different components of metabolic syndrome which are risk factors for cardiovascular diseases (CVDs).

Results: According to these studies, red pepper as well as capsaicin has ability to control of metabolic syndrome and its related disorders such as obesity, disrupted lipid profile, diabetes and its complications.

Conclusion: Red pepper has beneficial effects on metabolic syndrome and can decrease the risk of mortality due to cardiovascular diseases, but still more research projects need to be done and confirm its advantageous especially in humans.

Keywords: Capsicum annuum; Cardiovascular disease; Diabetes; Dyslipidemia; Hypertension; Metabolic syndrome; Obesity; Red pepper.

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Figures

Figure 1
Figure 1
Schematic description of traditional effects of Capsicumannuum
Figure 2
Figure 2
Chemical structures of capsaicinoids
Figure 3
Figure 3
Schematic description showing the mechanisms of Capsicum annuum antidiabetic effects GLP1: glucagon-like peptide-1; TRPV1: transient receptor potential vanilloid subtype 1
Figure 4
Figure 4
Schematic description showing the mechanisms of Capsicum annuum and capsaicin antidiabetic effects.
See this image and copyright information in PMC

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