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. 2019 Jan;29(1):401-410.
doi: 10.1007/s00330-018-5559-z. Epub 2018 Jun 19.

LI-RADS v2014 categorization of hepatocellular carcinoma: Intraindividual comparison between gadopentetate dimeglumine-enhanced MRI and gadoxetic acid-enhanced MRI

Ji Soo Song  1   2   3 , Eun Jung Choi  4   5   6 , Seung Bae Hwang  4   5   6 , Hong Pil Hwang  7 , HyeMi Choi  8
Affiliations

LI-RADS v2014 categorization of hepatocellular carcinoma: Intraindividual comparison between gadopentetate dimeglumine-enhanced MRI and gadoxetic acid-enhanced MRI

Ji Soo Song et al. Eur Radiol. 2019 Jan.

Abstract

Objectives: To use Liver Imaging Reporting and Data System (LI-RADS) categorization and features of hepatocellular carcinomas (HCCs) to intraindividually compare gadopentetate dimeglumine-enhanced magnetic resonance imaging (Gd-DTPA-MRI) and gadoxetic acid-enhanced MRI (Gd-EOB-MRI), before and after applying modified major features.

Methods: Of 77 HCCs in 64 patients analysed, 17 HCCs were confirmed histopathologically and 46 patients had cirrhosis. Gd-EOB-MRI and Gd-DTPA-MRI were evaluated for the presence of major and ancillary features by two radiologists. LI-RADS categorization was done for Gd-DTPA-MRI (LI-RADS-DTPA) and for Gd-EOB-MRI before and after applying modified major features (hepatobiliary phase [HBP] hypointensity as an additional major feature, LI-RADS-EOBm1; HBP hypointense rim as capsule appearance, LI-RADS-EOBm2; and transitional phase [TP] hypointensity as washout appearance, LI-RADS-EOBm3). Sensitivities of LR-5 categorization for the diagnosis of HCC were compared.

Results: Washout (p=0.012) and capsule appearance (p<0.001) were less frequently observed on Gd-EOB-MRI. Sensitivity for LR-5 categorization was significantly higher with LI-RADS-DTPA compared with LI-RADS-EOB (p=0.001) and LI-RADS-EOBm2 (p=0.004), while sensitivity for LR-5 categorization with LI-RADS-EOBm1 (p=0.210) and LI-RADS-EOBm3 (p=0.727) was comparable.

Conclusion: Modifying LI-RADS for use with Gd-EOB-MRI, such as applying HBP hypointensity as an additional major feature or using TP hypointensity as washout appearance, can improve the sensitivity for the detection of HCC.

Key points: • Adding HBP hypointensity as additional major feature improved sensitivity of LR-5 categorization. • Adding TP hypointensity as modified washout appearance improved sensitivity of LR-5 categorization. • Sensitivities for LR-5 classification were comparable between LI-RADS-DTPA, LI-RADS-EOBm1, and LI-RADS-EOBm3.

Keywords: Diagnosis; Gadopentetate dimeglumine; Hepatocellular carcinoma; Liver; Magnetic resonance imaging.

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References

    1. Invest Radiol. 2010 Mar;45(3):133-41 - PubMed
    1. J Hepatol. 2016 May;64(5):1099-1107 - PubMed
    1. Abdom Imaging. 2015 Mar;40(3):613-25 - PubMed
    1. Eur Radiol. 2017 Jun;27(6):2610-2618 - PubMed
    1. Dig Dis. 2014;32(6):764-77 - PubMed

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