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. 2019 Jul;39(7):1445-1450.
doi: 10.1007/s10792-018-0957-4. Epub 2018 Jun 19.

YKL-40 expression in pterygium: a potential role in the pathogenesis

Ali Kurt  1   2 , Raşit Kılıç  3 , Murat Tad  4 , Osman Ahmet Polat  3
Affiliations

YKL-40 expression in pterygium: a potential role in the pathogenesis

Ali Kurt et al. Int Ophthalmol. 2019 Jul.

Abstract

Purpose: The aim of the study was to evaluate whether YKL-40 (chitinase 3-like 1 protein) plays a role in pterygium pathogenesis.

Methods: We included 42 primary pterygium patients and 24 control subjects with normal bulbar conjunctiva in the study. The pterygium patients were classified into the atrophic, fleshy, and intermediate groups according to the Tan classification. We then surgically removed the primary nasal pterygium and normal bulbar conjunctiva from the patients and immunohistochemically investigated YKL-40 expression.

Results: YKL-40 expression was statistically significantly higher in the epithelial, endothelial, and stromal cells of the pterygium tissues than in the control tissues (P = 0.009, P = 0.003, P = 0.002, respectively). There was no significant correlation between the pterygium subgroups and YKL-40 expression (P > 0.05).

Conclusions: We believe YKL-40 may play a significant role in pterygium pathogenesis.

Keywords: Angiogenesis; Inflammation; Pterygium; YKL-40.

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References

    1. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2430-7 - PubMed
    1. Eye (Lond). 2007 Aug;21(8):1095-101 - PubMed
    1. Med Hypotheses. 2007;69(4):925-7 - PubMed
    1. Curr Eye Res. 2008 Jan;33(1):23-8 - PubMed
    1. Methods Mol Biol. 2009;511:159-84 - PubMed

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