Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1985 Jun;275(2):199-207.

Clonidine-induced desensitization differentiates presynaptic alpha-2 adrenoceptors of the guinea-pig ileum and rat vas deferens

M Ilhan, J P Long
  • PMID: 2992403
Comparative Study

Clonidine-induced desensitization differentiates presynaptic alpha-2 adrenoceptors of the guinea-pig ileum and rat vas deferens

M Ilhan et al. Arch Int Pharmacodyn Ther. 1985 Jun.

Abstract

Clonidine-induced inhibitions of twitch responses of coaxially stimulated guinea-pig ileum and transmurally stimulated rat vas deferens were antagonized by yohimbine in a competitive manner. In contrast to rat vas deferens, clonidine caused desensitization of presynaptic alpha 2-adrenoceptors on cholinergic neurons of guinea-pig ileum. Cross desensitization was observed between clonidine and oxymetazoline. No cross desensitization between clonidine and morphine was observed and indicates that presynaptic alpha 2-adrenoceptors are involved in clonidine-induced desensitization of the presynaptic site in the guinea-pig ileum.

PubMed Disclaimer

Publication types