doi: 10.1016/0006-291x(85)90495-4.
The presence of two mitochondrial DNA topoisomerases in human acute leukemia cells
- PMID: 2992488
- DOI: 10.1016/0006-291x(85)90495-4
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The presence of two mitochondrial DNA topoisomerases in human acute leukemia cells
Biochem Biophys Res Commun.
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Abstract
We have undertaken a study of DNA topoisomerases in mitochondria from human acute leukemia cells. Two activities have been detected in these organelles. One of the enzymes is presumably a type II topoisomerase, i.e., in ATP-dependent reactions it can catenate closed circular plasmid DNA, and decatenate closed circular kinetoplast DNA. A second topoisomerase is presumably a type I enzyme since, it can relax positive as well as negative supercoils in an ATP-independent reaction, it is unable to catenate plasmid DNA or decatenate kinetoplast DNA, and it is inhibited, rather than stimulated, by ATP.
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