Transcription Factor Theft-PU.1 Caught Red-Handed

Axel Kallies¹, Stephen L Nutt²

Affiliations

¹ Department of Microbiology and Immunology, The University of Melbourne and The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne VIC, Australia. Electronic address: kallies@wehi.edu.au.
² Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne VIC, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.

PMID: 29924967
DOI: 10.1016/j.immuni.2018.05.007

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Transcription Factor Theft-PU.1 Caught Red-Handed

Axel Kallies et al. Immunity. 2018.

Free article

. 2018 Jun 19;48(6):1063-1065.

doi: 10.1016/j.immuni.2018.05.007.

Authors

Axel Kallies¹, Stephen L Nutt²

Affiliations

¹ Department of Microbiology and Immunology, The University of Melbourne and The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne VIC, Australia. Electronic address: kallies@wehi.edu.au.
² Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne VIC, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.

PMID: 29924967
DOI: 10.1016/j.immuni.2018.05.007

Abstract

The mechanistic understanding of gene-expression regulation is still evolving. In this issue of Immunity, Hosokawa et al. (2018) reveal that PU.1 represses transcription indirectly during early T cell development by "stealing" other regulators such as Runx1 and Satb1 from their DNA binding sites.

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Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.
Hosokawa H, Ungerbäck J, Wang X, Matsumoto M, Nakayama KI, Cohen SM, Tanaka T, Rothenberg EV. Hosokawa H, et al. Immunity. 2018 Jun 19;48(6):1119-1134.e7. doi: 10.1016/j.immuni.2018.04.024. Immunity. 2018. PMID: 29924977 Free PMC article.

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Transcription Factor Theft-PU.1 Caught Red-Handed

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Transcription Factor Theft-PU.1 Caught Red-Handed

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