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Comment
. 2018 Jun 19;48(6):1070-1072.
doi: 10.1016/j.immuni.2018.05.015.

Defens-IN! Human α-Defensin 5 Acts as an Unwitting Double Agent to Promote Shigella Infection

Alison G Murphy  1 , Kevin J Maloy  2
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Defens-IN! Human α-Defensin 5 Acts as an Unwitting Double Agent to Promote Shigella Infection

Alison G Murphy et al. Immunity. .
Free article

Abstract

Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion.

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