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Comment
. 2018 Jun 19;48(6):1074-1076.
doi: 10.1016/j.immuni.2018.05.016.

Holy Immune Tolerance, Batman!

Haley E Randolph  1 , Luis B Barreiro  2
Affiliations
Comment

Holy Immune Tolerance, Batman!

Haley E Randolph et al. Immunity. .

Abstract

Bats are reservoir hosts of numerous viruses that cause severe pathology in humans. How bats cope with such pathogens remains elusive. In a recent issue of Cell, Pavlovich et al. (2018) describe several key adaptations in innate immune-related genes that suggest that the Egyptian rousette fruit bat relies on immune tolerance mechanisms to manage viral infections.

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Figures

Figure 1
Figure 1
Genomic Signatures of Viral Infection Tolerance Mechanisms in R. aegyptiacus Multiple adaptations in innate immune-related genes suggest that R. aegyptiacus employs immune tolerance strategies to control viral infections. Such strategies include (1) the expansion of the type I interferon family, (2) an abundance of NK cell receptors with inhibitory signaling capacities, and (3) the dispersion of MHC class I genes to non-canonical regions of the genome. (Design credit to M. Gutiérrez.)
See this image and copyright information in PMC

Comment on

  • The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.
    Pavlovich SS, Lovett SP, Koroleva G, Guito JC, Arnold CE, Nagle ER, Kulcsar K, Lee A, Thibaud-Nissen F, Hume AJ, Mühlberger E, Uebelhoer LS, Towner JS, Rabadan R, Sanchez-Lockhart M, Kepler TB, Palacios G. Pavlovich SS, et al. Cell. 2018 May 17;173(5):1098-1110.e18. doi: 10.1016/j.cell.2018.03.070. Epub 2018 Apr 26. Cell. 2018. PMID: 29706541 Free PMC article.

References

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