Tissue engineering toward temporomandibular joint disc regeneration
- PMID: 29925634
- PMCID: PMC6553461
- DOI: 10.1126/scitranslmed.aaq1802
Tissue engineering toward temporomandibular joint disc regeneration
Abstract
Treatments for temporomandibular joint (TMJ) disc thinning and perforation, conditions prevalent in TMJ pathologies, are palliative but not reparative. To address this, scaffold-free tissue-engineered implants were created using allogeneic, passaged costal chondrocytes. A combination of compressive and bioactive stimulation regimens produced implants with mechanical properties akin to those of the native disc. Efficacy in repairing disc thinning was examined in minipigs. Compared to empty controls, treatment with tissue-engineered implants restored disc integrity by inducing 4.4 times more complete defect closure, formed 3.4-fold stiffer repair tissue, and promoted 3.2-fold stiffer intralaminar fusion. The osteoarthritis score (indicative of degenerative changes) of the untreated group was 3.0-fold of the implant-treated group. This tissue engineering strategy paves the way for developing tissue-engineered implants as clinical treatments for TMJ disc thinning.
Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Conflict of interest statement
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Comment in
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Jaw-dropping new surgical approach.Nat Rev Rheumatol. 2018 Aug;14(8):444. doi: 10.1038/s41584-018-0055-z. Nat Rev Rheumatol. 2018. PMID: 30002463 No abstract available.
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