Neuroimmune disorders of the central nervous system in children in the molecular era

Elizabeth Wells¹, Yael Hacohen^{2

3}, Amy Waldman⁴, Jan M Tillema⁵, Ariane Soldatos⁶, Beau Ances⁷, Susanne Benseler⁸, Bibi Bielekova⁹, Russel C Dale¹⁰, Josep Dalmau^{11

12}, William Gaillard¹, Mark Gorman¹³, Benjamin Greenberg¹⁴, Ann Hyslop¹⁵, Carlos A Pardo¹⁶, Robert C Tasker¹⁷, E Ann Yeh¹⁸, Amit Bar-Or¹⁹, Sean Pittock^{5

20}, Adeline Vanderver⁴, Brenda Banwell²¹; attendees of the International Neuroimmune Meeting

Collaborators, Affiliations

Collaborators

attendees of the International Neuroimmune Meeting:
Jessica Carpenter, Irene Cortese, Nathan Dean, Racquel Farias-Moeller, William Gallentine, Carol Glaser, Raphaela Goldbach-Mansky, Ilana Kahn, Bennett Lavenstein, William McClintock, William McDow, Jennifer Murphy, Avindra Nath, Roger Packer, Tova Ronis, David Schleyer, Stephanie Schleyer, Peter Shibuya, Ursula Utz, Gilbert Vezina, David Wessel

Affiliations

¹ Center for Neuroscience and Behavioral Medicine, Children's National Health System, Washington, DC, USA.
² Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, UK. y.hacohen@ucl.ac.uk.
³ Paediatric Neurology, Great Ormond Street Hospital, London, UK. y.hacohen@ucl.ac.uk.
⁴ Department of Neurology and Pediatric Multiple Sclerosis Clinic, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁵ Department of Neurology, Mayo Clinic, Rochester, MN, USA.
⁶ National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
⁷ Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
⁸ Section of Rheumatology, Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta, Canada.
⁹ Neuroimmunological Diseases Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
¹⁰ Institute for Neuroscience and Muscle Research, Kids Research Institute at the Children's Hospital at Westmead, University of Sydney, Westmead, New South Wales, Australia.
¹¹ ICREA-IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain.
¹² Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
¹³ Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
¹⁴ Department of Neurology and Neurotherapeutics and Department of Pediatrics, University of Texas Southwestern, Dallas, TX, USA.
¹⁵ Department of Pediatric Neurology and Epilepsy, Miami Children's Hospital, Miami, FL, USA.
¹⁶ Johns Hopkins Transverse Myelitis Center, Baltimore, MD, USA.
¹⁷ Department of Neurocritical Care, Boston Children's Hospital, Boston, MA, USA.
¹⁸ Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
¹⁹ Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
²⁰ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
²¹ Department of Neurology and Pediatric Multiple Sclerosis Clinic, Children's Hospital of Philadelphia, Philadelphia, PA, USA. BanwellB@email.chop.edu.

PMID: 29925924
DOI: 10.1038/s41582-018-0024-9

Review

Neuroimmune disorders of the central nervous system in children in the molecular era

Elizabeth Wells et al. Nat Rev Neurol. 2018 Jul.

. 2018 Jul;14(7):433-445.

doi: 10.1038/s41582-018-0024-9.

Authors

Collaborators

attendees of the International Neuroimmune Meeting:
Jessica Carpenter, Irene Cortese, Nathan Dean, Racquel Farias-Moeller, William Gallentine, Carol Glaser, Raphaela Goldbach-Mansky, Ilana Kahn, Bennett Lavenstein, William McClintock, William McDow, Jennifer Murphy, Avindra Nath, Roger Packer, Tova Ronis, David Schleyer, Stephanie Schleyer, Peter Shibuya, Ursula Utz, Gilbert Vezina, David Wessel

Affiliations

¹ Center for Neuroscience and Behavioral Medicine, Children's National Health System, Washington, DC, USA.
² Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, UK. y.hacohen@ucl.ac.uk.
³ Paediatric Neurology, Great Ormond Street Hospital, London, UK. y.hacohen@ucl.ac.uk.
⁴ Department of Neurology and Pediatric Multiple Sclerosis Clinic, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁵ Department of Neurology, Mayo Clinic, Rochester, MN, USA.
⁶ National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
⁷ Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
⁸ Section of Rheumatology, Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta, Canada.
⁹ Neuroimmunological Diseases Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
¹⁰ Institute for Neuroscience and Muscle Research, Kids Research Institute at the Children's Hospital at Westmead, University of Sydney, Westmead, New South Wales, Australia.
¹¹ ICREA-IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain.
¹² Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
¹³ Department of Neurology, Boston Children's Hospital, Boston, MA, USA.
¹⁴ Department of Neurology and Neurotherapeutics and Department of Pediatrics, University of Texas Southwestern, Dallas, TX, USA.
¹⁵ Department of Pediatric Neurology and Epilepsy, Miami Children's Hospital, Miami, FL, USA.
¹⁶ Johns Hopkins Transverse Myelitis Center, Baltimore, MD, USA.
¹⁷ Department of Neurocritical Care, Boston Children's Hospital, Boston, MA, USA.
¹⁸ Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
¹⁹ Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
²⁰ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
²¹ Department of Neurology and Pediatric Multiple Sclerosis Clinic, Children's Hospital of Philadelphia, Philadelphia, PA, USA. BanwellB@email.chop.edu.

PMID: 29925924
DOI: 10.1038/s41582-018-0024-9

Erratum in

Author Correction: Neuroimmune disorders of the central nervous system in children in the molecular era.
Wells E, Hacohen Y, Waldman A, Tillema JM, Soldatos A, Ances B, Benseler S, Bielekova B, Dale RC, Dalmau J, Gaillard W, Gorman M, Greenberg B, Hyslop A, Pardo CA, Tasker RC, Yeh EA, Bar-Or A, Pittock S, Vanderver A, Banwell B; attendees of the International Neuroimmune Meeting. Wells E, et al. Nat Rev Neurol. 2018 Dec;14(12):749. doi: 10.1038/s41582-018-0077-9. Nat Rev Neurol. 2018. PMID: 30442924

Abstract

Immune-mediated disorders of the CNS in children are a complex group of demyelinating, inflammatory, parainfectious and postinfectious disorders with heterogeneous pathobiological mechanisms and clinical manifestations, often associated with fundamental derangement in immune regulation. In this Review, we aim to provide an update on our knowledge of neuroimmune disorders and highlight areas of research that are priorities for improving clinical management. We outline the clinical features of neuroimmune disorders, the current approaches to their treatment and new approaches in development. We then consider the pathological features, including biomarkers, pathological mechanisms and genetics, and discuss the value of immune assays in clinical investigation and basic research. On the basis of current knowledge and techniques, we propose four research priorities: rigorous and consistent collection of core clinical data, cooperative investigation of treatments, development of biological assays and genetic studies. These priorities should help us to achieve the shared goal of precision medicine for neuroimmune disorders. However, multicentre research and the creation of clinical consortia for these rare disorders will be necessary, and we hope that this Review serves as a call to action that is timely given current exciting advances in neuroimmune therapeutics.

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Neuroimmune disorders of the central nervous system in children in the molecular era

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Neuroimmune disorders of the central nervous system in children in the molecular era

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