doi: 10.1007/BF00320120.
A monoclonal antibody D51 recognizes the transferrin-receptor structure
- PMID: 2992646
- DOI: 10.1007/BF00320120
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A monoclonal antibody D51 recognizes the transferrin-receptor structure
Blut.
1985 Aug.
Abstract
A monoclonal antibody D51 has been obtained during immunization against human fetal thymus. The antibody binds to a variety of leukemic cells. This is similar to the staining pattern of the mAb OKT9 and L 5.1, which recognize the transferrin receptor. However, there are some differences. The antibody immunoprecipitates a protein present on Molt-4 cells. Under reducing conditions this protein has a molecular weight of 90 K dalton. Under non-reducing conditions it has a molecular weight of 180 K dalton. This suggests a dimeric structure. The consecutive immunoprecipitation with D51 and OKT9, respectively, demonstrates that both antibodies recognize the structure of the transferrin receptor.
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