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. 1985 Aug;51(2):117-22.
doi: 10.1007/BF00320120.

A monoclonal antibody D51 recognizes the transferrin-receptor structure

H J Gross

A monoclonal antibody D51 recognizes the transferrin-receptor structure

H J Gross. Blut. 1985 Aug.

Abstract

A monoclonal antibody D51 has been obtained during immunization against human fetal thymus. The antibody binds to a variety of leukemic cells. This is similar to the staining pattern of the mAb OKT9 and L 5.1, which recognize the transferrin receptor. However, there are some differences. The antibody immunoprecipitates a protein present on Molt-4 cells. Under reducing conditions this protein has a molecular weight of 90 K dalton. Under non-reducing conditions it has a molecular weight of 180 K dalton. This suggests a dimeric structure. The consecutive immunoprecipitation with D51 and OKT9, respectively, demonstrates that both antibodies recognize the structure of the transferrin receptor.

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