[The effects of 5-HT1B receptor subtypes on motor behaviors mediated by cerebellar fastigial nucleus]
- PMID: 29926625
- DOI: 10.13459/j.cnki.cjap.2016.06.014
[The effects of 5-HT1B receptor subtypes on motor behaviors mediated by cerebellar fastigial nucleus]
Abstract
Objective: To investigate the effects of the serotonergic nervous system on motor behaviors mediated by cerebellar fastigial nucleus (FN).
Methods: In this experiment, the main methods are whole-cell patch clamp recording and Rota-rod test.
Results: We found that the excitatory synaptic transmission was enhanced in the cerebella FN after blocking 5-hydroxytryptamine,(5-HT)receptor. Microinjection of 5-HT into FNs remarkably promoted motor performances on Rota-rod, which could be reversed by microinjection of 5-HT receptor antagonist SB224289.
Conclusions: These results suggest that the 5-HT can suppress cerebellar FN excitatory synaptic transmission via 5-HT1B receptors, thereby modulate the activity of cerebellar nuclear neurons circuitry, and subsequently influence the cerebellum-mediated ongoing motor balance and coordination.
Keywords: 5-HT; 5-HT1B receptor; excitatory post-synaptic currents; fastigial nucleus (FN); patch clamp; rat.
Similar articles
-
5-HT2A receptor-mediated excitation on cerebellar fastigial nucleus neurons and promotion of motor behaviors in rats.Pflugers Arch. 2014 Jul;466(7):1259-71. doi: 10.1007/s00424-013-1378-x. Epub 2013 Oct 22. Pflugers Arch. 2014. PMID: 24145983
-
Histamine promotes rat motor performances by activation of H(2) receptors in the cerebellar fastigial nucleus.Behav Brain Res. 2012 Mar 1;228(1):44-52. doi: 10.1016/j.bbr.2011.11.029. Epub 2011 Nov 29. Behav Brain Res. 2012. PMID: 22146592
-
Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes.Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):220-7. doi: 10.1007/s00210-003-0842-0. Epub 2003 Dec 12. Naunyn Schmiedebergs Arch Pharmacol. 2004. PMID: 14673512
-
Serotonin1B receptors: from protein to physiological function and behavior.Neurosci Biobehav Rev. 2004 Oct;28(6):565-82. doi: 10.1016/j.neubiorev.2004.08.008. Neurosci Biobehav Rev. 2004. PMID: 15527863 Review.
-
5-HT receptors mediating external carotid vasoconstriction in vagosympathectomized dogs.Zhongguo Yao Li Xue Bao. 1999 Dec;20(12):1057-67. Zhongguo Yao Li Xue Bao. 1999. PMID: 11216445 Review.
Cited by
-
Percutaneous mastoid electrical stimulator improves Poststroke depression and cognitive function in patients with Ischaemic stroke: a prospective, randomized, double-blind, and sham-controlled study.BMC Neurol. 2020 May 29;20(1):217. doi: 10.1186/s12883-020-01795-0. BMC Neurol. 2020. PMID: 32471373 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
