Evolution of the SYNERGY bioresorbable polymer metallic coronary stent

Abstract

The SYNERGY stent is composed of thin, platinum-chromium metal alloy struts and an ultrathin, bioabsorbable poly-DL-lactide-co-glycolide polymer limited to the abluminal strut surface which elutes everolimus prior to complete resorption within 3-4 months. SYNERGY was designed to reduce inflammation and facilitate stent healing compared with permanent polymer drug eluting stents. This review summarizes the preclinical and clinical development of SYNERGY, its integration into clinical practice and future directions.

Keywords: SYNERGY; bioresorbable polymer metallic coronary stent; cardiac catheterization; drug eluting stent; percutaneous coronary interventions; stents.