Short article: Hepatitis delta in patients with resolved hepatitis B virus infection
- PMID: 29927770
- DOI: 10.1097/MEG.0000000000001187
Short article: Hepatitis delta in patients with resolved hepatitis B virus infection
Abstract
Background: The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset shows elevated liver enzymes and hepatic fibrosis. Could they represent HBsAg-seronegative occult HDV infections?
Methods: We tested for HDV-antibodies 406 individuals with markers of past HBV exposure.
Results: Overall, 20 (4.9%) were reactive for HDV-antibodies. All were negative for serum HDV-RNA, including four with elevated liver enzymes.
Conclusion: These results support the current policy of screening for hepatitis delta only in HBsAg+ individuals.
Comment in
-
Delta hepatitis in resolved hepatitis B.Eur J Gastroenterol Hepatol. 2018 Dec;30(12):1528. doi: 10.1097/MEG.0000000000001253. Eur J Gastroenterol Hepatol. 2018. PMID: 30395014 No abstract available.
Similar articles
-
Determination of hepatitis delta virus (HDV)-RNA in asymptomatic cases of HDV infection.Am J Gastroenterol. 1997 Dec;92(12):2232-6. Am J Gastroenterol. 1997. PMID: 9399760
-
Molecular epidemiological and clinical aspects of hepatitis D virus in a unique triple hepatitis viruses (B, C, D) endemic community in Taiwan.J Med Virol. 2003 May;70(1):74-80. doi: 10.1002/jmv.10361. J Med Virol. 2003. PMID: 12629646
-
Characterization of hepatitis B and delta coinfection in Israel.BMC Infect Dis. 2018 Feb 27;18(1):97. doi: 10.1186/s12879-018-3008-x. BMC Infect Dis. 2018. PMID: 29486716 Free PMC article.
-
Hepatitis delta virus diagnosis.Semin Liver Dis. 2012 Aug;32(3):220-7. doi: 10.1055/s-0032-1323627. Epub 2012 Aug 29. Semin Liver Dis. 2012. PMID: 22932970 Review.
-
An update on HDV: virology, pathogenesis and treatment.Antivir Ther. 2013;18(3 Pt B):541-8. doi: 10.3851/IMP2598. Epub 2013 Jun 21. Antivir Ther. 2013. PMID: 23792471 Review.
Cited by
-
Highlights from the 20th International Symposium on HIV and Emerging Infectious Diseases (ISHEID) 16-18 May 2018, Marseille, France: from HIV and comorbidities to global health.J Virus Erad. 2018 Jul 1;4(3):196-207. doi: 10.1016/S2055-6640(20)30271-5. J Virus Erad. 2018. PMID: 30050686 Free PMC article.
-
The Management of Chronic Hepatitis B: 2025 Guidelines Update from the Canadian Association for the Study of the Liver and Association of Medical Microbiology and Infectious Disease Canada.Can Liver J. 2025 May 26;8(2):368-440. doi: 10.3138/canlivj-2025-0012-e. eCollection 2025 May. Can Liver J. 2025. PMID: 40677987 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
