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Comment
. 2018 Jun 21;14(6):e1007415.
doi: 10.1371/journal.pgen.1007415. eCollection 2018 Jun.

The long and short of lifespan regulation by Argonautes

Kristen C Brown  1   2 , Taiowa A Montgomery  1
Affiliations
Comment

The long and short of lifespan regulation by Argonautes

Kristen C Brown et al. PLoS Genet. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Opposite roles for 2 Argonautes in C. elegans lifespan regulation.
miRNAs are processed from hairpin precursors and sorted between Argonautes, primarily ALG-1 and ALG-2. Loss of alg-1 activity leads to a shortened lifespan, indicating that ALG-1 normally promotes longevity. Conversely, loss of alg-2 activity extends lifespan, indicating that ALG-2 acts counter to ALG-1 to limit lifespan. Both Argonautes function at least in part through the insulin signaling pathway involving the insulin/IGF receptor DAF-2, which limits lifespan, and the forkhead transcription factor DAF-16/FOXO, which promotes extended lifespan. It is possible that ALG-1 and ALG-2 also affect longevity via regulation of parallel pathways involved in aging, as indicated by the dashed lines.
See this image and copyright information in PMC

Comment on

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